WHO chief lists main threats from H1N1 flu (Swine Flu) 18 May 2009
H1N1 virus in sewage

1918 Flu Resulted In Current Lineage Of H1N1 Swine Influenza Viruses
ScienceDaily (May 1, 2009) — In 1918 a human influenza virus known as the Spanish flu spread through
the central United States while a swine respiratory disease occurred concurrently. A Kansas State University
researcher has found that the virus causing the pandemic was able to infect and replicate in pigs, but did
not kill them, unlike in other mammalian hosts like monkeys, mice and ferrets where the infection has been
lethal.


Drug-resistant Influenza A Virus Potentially Serious To High-risk Patients
ScienceDaily (Mar. 2, 2009) — A mutation of the influenza A(H1N1) virus that is resistant to the drug
oseltamivir may pose a serious health threat to hospitalized patients who have a weakened immune system,
according to a new study.

Tamiflu Survives Sewage Treatment
ScienceDaily (Oct. 4, 2007) — Swedish researchers have discovered that oseltamivir (Tamiflu); an antiviral
drug used to prevent and mitigate influenza infections is not removed or degraded during normal sewage
treatment. Consequently, in countries where Tamiflu is used at a high frequency, there is a risk that its
concentration in natural waters can reach levels where influenza viruses in nature will develop resistance to
it.

Study Of Flu Patients Reveals Virus Outsmarting Key Drug
ScienceDaily (Sep. 13, 2004) — MADISON - A drug envisioned as a front-line defense for the next flu
pandemic might have a genetic Achilles' heel that results in a drug-resistant influenza virus capable of
infecting new human hosts, according to a study published this week (Aug. 28) in the British medical journal
The Lancet.