Megasphaera

Megasphaera --  inhabitants of oral cavity, respiratory tract, intestinal tract of humans, ruminants. Rodents and pigs

http://www.textbooksonline.tn.nic.in/Books/11/MicroBio-EM/chapter%208.pdf


Megasphaera [M0449493] A genus of gram-negative bacteria in the family ACIDAMINOCOCCACEAE, found
in the RUMEN of SHEEP and CATTLE, and also in humans.
http://www.slicksurface.com/medical-thesaurus/semantic-type/bacterium.htm


Association between Lactobacillus species and bacterial vaginosis-related bacteria, and bacterial
vaginosis scores in pregnant Japanese women.
BMC Infect Dis. 2007 Nov 7;7(1):128. ABSTRACT:
BACKGROUND: Bacterial vaginosis (BV), the etiology of which is still uncertain, increases the risk of preterm birth.
Recent PCR-based studies suggested that BV is associated with complex vaginal bacterial communities, including
many newly recognized bacterial species in non-pregnant women. METHODS: To examine whether these bacteria are
also involved in BV in pregnant Japanese women, vaginal fluid samples were taken from 132 women, classified as
normal (n=98), intermediate (n=21), or BV (n=13) using the Nugent gram stain criteria, and studied. DNA extracted
from these samples was analyzed for bacterial sequences of any Lactobacillus, four Lactobacillus species, and four
BV-related bacteria by PCR with primers for 16S ribosomal DNA including a universal Lactobacillus primer,
Lactobacillus species-specific primers for L. crispatus, L. jensenii, L. gasseri, and L. iners, and BV-related
bacterium-specific primers for BVAB2,
Megasphaera, Leptotrichia, and Eggerthella-like bacterium. RESULTS: The
prevalences of L. crispatus, L. jensenii, and L. gasseri were significantly higher, while those of BVAB2, Megasphaera,
Leptotrichia, and Eggerthella-like bacterium were significantly lower in the normal group than in the BV group. Unlike
other Lactobacillus species, the prevalence of L. iners did not differ between the three groups and women with L.
iners were significantly more likely to have BVAB2, Megasphaera, Leptotrichia, and Eggerthella-like bacterium. Linear
regression analysis revealed associations of BVAB2 and
Megasphaera with Nugent score, and multivariate
regression analyses suggested a close relationship between Eggerthella-like bacterium and BV. CONCLUSIONS: The
BV-related bacteria, including BVAB2,
Megasphaera, Leptotrichia, and Eggerthella-like bacterium, are common in
the vagina of pregnant Japanese women with BV. The presence of L. iners may be correlated with vaginal colonization
by these BV-related bacteria.
BMC Infect Dis. 2007 Nov 7;7:128.
[Abstract/Link to Full Text]