http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=245475

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, OCt. 1992, p. 2197-2200
0066-4804/92V102197-04$02.00/0
Copyright © 1992, American Society for Microbiology
Vol. 36, No. 10
Antimicrobial Susceptibilities and 13-Lactamase Characterization
of Capnocytophaga Species
DIANE L. ROSCOE,lt* S. JANET V. ZEMCOV,1 DAWN THORNBER,2
RICHARD WISE,2 AND ALISON M. CLARKE1
Division ofMedical Microbiology, St. Paul's Hospital, Vancouver, British Columbia, Canada, 1 and
Department of Medical Microbiology, Dudley Road Hospital, Birmingham, England2


Capnocytophaga species are part of the normal oral flora
of humans and animals and have been implicated in the
polymicrobial etiology of gingivitis and localized periodontitis
(25). Systemic infections were first reported for immunocompromised
hosts, usually in association with severe
chemotherapy-induced oral ulcerations (1, 10, 12). Subsequently,
Capnocytophaga spp. were recognized as the cause
of a variety of infections in the immunocompetent host,
including bacteremia (28), endocarditis (7), mediastinal abscess
(24), septic arthritis (34), peritonitis (23), pyonephrosis
(33), inguinal lymphadenopathy (17), necrotizing keratitis
(15, 29), and a number of peripartum infections leading to
chorioamnionitis, prematurity, and sepsis in the newborn (8,
13, 21, 22). Therapy of these infections is often empiric and
it is therefore important to know which antibiotics are
predictably active against Capnocytophaga spp. Five major
studies of the antimicrobial susceptibility of Capnocytophaga
spp. have shown that these organisms are typically
susceptible to penicillin, clindamycin, chloramphenicol, the
quinolones, and expanded-spectrum cephalosporins, while
susceptibility to narrow-spectrum cephalosporins is variable
(2, 9, 14, 30, 32). Only 4 of the 287 strains described in these
studies produced a 1-lactamase (2, 30), and septicemia due
to ,-lactamase-producing Capnocytophaga spp. was not
reported until 1987 (3). Consequently, the isolation of ,-lactamase-
producing Capnocytophaga spp. from two different
patients with neutropenic sepsis at the teaching hospitals of
the University of British Columbia caused concern and
prompted this investigation into the antibiotic susceptibility
of Capnocytophaga spp. in Canada.
(This work was presented in part at the 58th Conjoint
Meeting on Infectious Diseases, Halifax, Nova Scotia, Canada,
25 to 29 November 1990.)